Conference Schedule

Day1: October 22, 2018

Keynote Forum

Biography

Professor of Neurology, Head of the 1st University Department of Neurology, Neuropsychiatrist and theologist, and she has worked at Aristotle University of Thessaloniki since 1982. She has been the main author of many Books (48), many abstracts in Greek (513) and International (446) Conferences, she is the first author or co-author in many Papers in Greek (186) and International Journals (363) with h-index=47, and more than 15.000 citations, (Scopus). Totally 52 awards. She participated in many European, American and Greek funded programs such as ICTUS, DESCRIPA, SHARE, ENIR, ADNeuromed, BIOMARK-APD, AD-gaming, MIRAGE, I-Connect, ASPAD, CBP, EN-NOHSHS, EMIF, EPAD etc. She created Greek Alzheimer Association in 1995, and Greek Federation in 2007 -she is now the chair of this foundation- and she is scientific director of two Dementia Units for outpatients. She is member of National Observatory for dementia. She has four children and 8 grandchildren

Abstract

Cognitive decline and dementia are among leading chronic conditions undermining the quality of life in our aging population. Despite the enormous financial expenses and the effort of world scientific and medical community, a 30 year period of active research into the neurobiology and neuropharmacology of AD did not result in the development of a therapy. Over 150 unsuccessful compounds were tested and a cure for dementia has yet to be discovered. Identifying modifiable risk factors towards disease prevention is a high priority. AD appears to be a complex and multifactorial disorder. Both environmental and hereditary factors are believed to be involved in the pathogenesis of AD. Among the most common pathogenic factors are:  insoluble deposits of beta amyloidal plaques; intracellular neurofibrillary tangles; loss of synapses; brain inflammation; neuronal loss; altered cholesterol metabolism; formation of reactive oxygen species (ROS) due to oxidative stress; presence of metal ions; depletion of neurotransmitters; mitochondrial dysfunction; protein glycation; apolipoprotein E polymorphic allele risk. Aging also has a strong influence on AD development. Efforts to develop new therapies to combat AD suffer from high failure rates that make it difficult to justify continued investment in the field. One possible explanation is the possibility that treatments aimed at a single pathologic process will be ineffective. For example, the most popular, the first and dominant hypotheses in the area of AD is the amyloid hypothesis, which posits that either the overproduction and/or the under clearance of amyloid β (Aβ) is a proximate cause of AD. However, we have no benefit targeting Αβ. Hippocrates many centuries ago said that food should be your medicine and if you need medicine, take it from food. Natural products have provided an invaluable source of inspiration in the drug discovery pipeline. Currently, functional foods to prevent and/or treat many conditions including neurodegenerative diseases represent a promising field of study, which is gaining attention. Many dietary components as well as a Mediterranean diet are a good source of antioxidants and are effective in inhibiting stress and have antiinflammatory properties showing substantial potential against AD pathogenesis such as Aβ accumulation and toxicity and tau phosphorylation. These dietary components are also associated with reductions in other pathophysiological conditions of AD while improving memory, learning ability, cognitive function and protecting against neuronal cell death. I have to present two Greek studies and their results with 1. Crocus Sativus and 2. Early harvest Extra Olive Oil.

 

Biography

Hadi Eltonsi, a Medical Graduate trained in group psychotherapy
, hypnosis, silva mind control, NLP, Reiki Master, Pranic Healing,
Life Couch, Mantra Yuga meditation among others courses
for psychic powers, family constellation through his medical
study and practice then as a Diplomat and Ambassador. He has
performed many TV, Radio interviews and seminars apart of
two short American films about his work or inspired by his skills
which were shown in international film festivals, got the second
award in Venice 2017.

Abstract

Purpose of the treatment: Achieving immediate non medicinal effortless painless
healing without complications for personality development, relief of neuorotic
disease, psychosomatic symptoms and diseases, treating emotional obesity and
smoking.
Method: After joint analysis with client and definition of psychological and
physical goals of treatment, the healer as a trained behavioural, cognitive and
logo psychotherapist arrives with client to a new corrected understanding of the
case and roots of conflicts in childhood, taking around 2 hours, then in less than
an hour performs nonverbal interpersonal hypnosis with transfer of energy and
telepathy to client till deep sleep when he implants the required personality, ideas,
emotions, motives and attitudes into the subconscious embodying the required
state. The subconscious and conscious mind will have same agreed upon analysis
and targets for immediate results in that session of 3 hours.
Results: The healer got patent in Egypt 2016 for his discovery of the immediate
healing for personality development and for mentioned purposes. Up till now
treating more than 700 cases aging between 12 and 80 years with relief of more
than 80% of cases either totally or mostly.

Biography

Jo Ferrie is a Sociologist based at the University of Glasgow.
She has worked within the disability studies field for 15 years,
examining the socially constructed barriers that turn impairment
into disability, with the aim of removing these barriers. In 2013,
she has published the largest global qualitative study of the
experience of living with motor neurone disease. She joined
the Euan MacDonald Centre as a PI in 2012, and worked on
a number of projects with them. She has worked with MND
Scotland and Anne Rowling Clinic to further understand the
impact of neurological conditions on people and their families.
She is also Director of Glasgow Q-Step (a £3 million Centre to
create a step change in how social science graduates use and
understand quantitative data) and is seconded to the University
of Edinburgh as Deputy Director – Training of the Scottish
Graduate School of Social Sciences..

Abstract

Adults diagnosed with neurological conditions can face a time limited future
with few treatment options. Their experience of receiving a diagnosis is
distressing, even when given well. Distress is exacerbated by waiting times,
notions of illegitimacy, progressive and frightening symptoms. This paper draws
on a number of studies, using phenomenological qualitative interviews of over 65
families across Scotland (around 15% of families who live with MND in Scotland)
in between 2011-2018. The research focusses on the social model of disability,
to determine where barriers to being and doing are constructed for participants,
and what can be done to remove them. It will reflect particularly on the added
value to adults who face dysarthria: voice degradation through impairment (for
example through Motor Neurone Disease (Also known as ALS/MND)), -by using a
voice recording of their own voice, to generate speech. Many rely on augmentative
and alternative communication (AAC) to express themselves. However, the use
of voice output communication aids (VOCAs) while facilitating communication,
cannot currently preserve the identity of the individual, as users are restricted to
a limited set of impersonal synthetic voices. The Speak Unique project (Led by Dr
Rewaj, Euan MacDonald Centre) has explored the value of producing a synthesized
voice, built around a person’s own voice, (after recording of a finite number of
sentences chosen for their ability to be deconstructed phonetically, for those
phonetic building blocks to be reconstructed to produce infinite sentences). This
paper presents an evaluation of this work, amongst other studies into the lived
experience of neurological conditions. A diagnosis of a neurological condition is
sufficient to trigger a biographical disruption (Bury, 1982) but there are services
that enable feelings of control and hope. The impact of recovering their own voice
was significant for families, impacting positively on wellbeing, social identity and intimacy

Biography

I have an experience of Neurosurgery for 9 years in educational
hospitals, studying MD of Neurosurgery cairo university,Msc of
Neurosurgery , member of ESA os spine,member of ESNS of
neurosurgeons, alot of conferences about Neurosurgery and
spine Administrator of Egyptian&World Neurosurgeons®Community
on telegram

Abstract

The second most common form of stroke (≈ 15–30% of all strokes) (earlier
estimates: 10%1), and the most deadly. Approximately 12–15 cases per
100,000/yr. alot of risk factors have been identified, according to site and GCS
prognosis will be expected, when size exceeds 30cc will you operate it or not, with
advancement of different facilities to control blood pressure and anaesthesia
make surgical options is more preferable, but you have to choose different plan
for every case,how to plan for every case it needs a lot of evaluation ,concept of
that with sizable ICH you will choose medical management due to bad prognosis
must be changed according to every case circumstances, clinical considerations
has the upper hand for what to do to every patient

Tracks

  • Cerebrovascular Disorders | Stroke Rehabilitation & Recovery | CNS(Central nervous system) | Stoke and Cerebral Hemorrhage | Spine & Spinal Disorders | Neurological Disorders | Dementia | Stroke
Location: Attica AB
Speaker

Ivet Borissova Koleva

Medical University, Bulgaria

Chair

Speaker

Magda Tsolaki

Department of Neurology, Thessaloniki, Greece

Co Chair

Biography

Ivet Borissova Koleva is a Medical Doctor, Specialist in Neurology and in Physical and Rehabilitation Medicine (PRM), with 30 years of clinical practice in the domain
of Neurorehabilitation. She has completed a PhD thesis on physical prevention and therapy of diabetic polyneuropathy and a thesis for Doctor of Medical Sciences on
Neurorehabilitation in Patients with Socially Important Neurological Diseases. She received the titles of Associate Professor (2006) and Professor (2010) in PRM. Currently, she
is serving as a Professor in the Medical University of Sofia, Bulgaria. She is the author of many scientific papers, monographs and manuals in the fields of neurorehabilitation,
neuro-ergotherapy, grasp and gait rehabilitation, functional evaluation, pain management. She is the Member of national and international associations of PRM and President of
Bulgarian Neurorehabilitation Society and Editor-in-chief of the Bulgarian scientific journal Neurorehabilitation since 2006.

Abstract

Introduction: Stroke is a socially important disease in industrialized countries, with a high level of prevalence and mortality.
Motor weakness and spasticity provoke pathokinesiological dysbalance in the upper extremity, with severe difficulty in everyday
activities of stroke survivors.
Aim: Our goal was to evaluate the impact of mirror therapy and functional electrostimulations in the complex neurorehabilitation
algorithm in patients with post-stroke hemiparesis, hemiparetic shoulder and hemiparetic hand.
Material & Methods: A total of 171 post-stroke patients with hemiparetic shoulder and hemiparetic hand were observed. Patients
were randomized into four therapeutic groups (57 per group). The control was done before, during and at the end of the NR course
(of 20 treatment days), and one month after its end-using a battery of clinical methods and functional scales. In all patients, we
applied a complex neurorehabilitation (NR) program of physiotherapy, cryotherapy and ergotherapy; including proprioceptive
neuromuscular facilitation (Kabath), strength and endurance exercises for shoulder abductors and rotators (rotator cuff muscles),
wrist and fingers extensors and flexors, lateral trunk and scapular muscles; grip and grasp training and goal-oriented activities.
Group (gr) 1 received only this NR programme. In gr 2, we applied mirror therapy for the hemiparetic hand. In the next group (gr
3), we added functional electrostimulations for the deltoid muscle, for extensors of the wrist and fingers.
Results & Discussion: The comparative analysis of results demonstrates significant pain reduction (visual analogue scale);
diminution of spasticity and contracture (Aschworth scale); increase of the range of motion (ROM) of the humeroscapular joint, of
the wrist and fingers (goniometry); recovery of the humeroscapular rhythm and the grasp kinesiology; improvement of functional
capacity (Brunnstrom), grasp capacity (Box and Block test) and autonomy (FIM)-self-care subscale; Barthel index-subscales grooming, eating, getting dressed, bathing).

Biography

Alok Sharma is the Director of NeuroGen Brain and
Spine Institute, Professor and Head of Department of
Neurosurgery, LTMG Hospital and LTM Medical College.
He has completed his MS and MCh from KEM Hospital
and Seth GS Medical College, Mumbai and subsequently
trained at the Karolinska University Hospital, Sweden and
University of Colorado Health Sciences Center, USA. He has
published 112 scientific papers, authored 14 books, edited
2 books, contributed chapters in 8 books and made over
150 scientific presentations nationally and internationally.
He is Founding President of the Stem Cell Society
(India) and Vice President of International Association of
Neurorestoratology. He is Founder of The Indian Journal
of Stem Cell Therapy and on the Editorial Board of four
journals. He has been conferred with numerous awards and
honors during his career. His other areas of special interest
are Neuroendoscopy, Psychosurgery, Spinal fixations and
Revascularization for cerebral ischemia.

Abstract

Stem cell therapy has emerged as a promising treatment option for various
incurable neurological disorders. We have studied the safety and efficacy
of intrathecal transplantation of autologous bone marrow mononuclear cells
in these disorders and will present our data. In neurodevelopmental disorders
such as autism spectrum disorder (ASD), out of 32 cases of ASD, 92% cases
showed improvement in different aspects of Indian scale for assessment of
autism (ISAA) along with improved scores of clinical global impression (CGI)
and functional independence measure (FIM) indicating cognitive and functional
improvements; in cerebral palsy, out of 40 cases of CP, 95% patients showed
improved oromotor activities, neck control, sitting, standing, walking balance
and speech with improved metabolism recorded in the PET-CT scan of brain;
in intellectual disability (ID), outcome of 29 patients of the intervention group
was compared to that of 29 patients from only rehabilitation group and it was
found that all patients in the intervention group showed improvement while,
there was no improvement in 20.69% patients from only rehabilitation group.
In neuromuscular disorders such as muscular dystrophy (MD), out of 150 MD
patients, 86.67% showed improved strength in trunk, upper and lower limbs and
gait; in amyotrophic lateral sclerosis (ALS), comparison of the survival analysis
was performed between the treated population (n=37) and the control group
(n=20). It was found that the survival duration of the treated population was
30.38 months more than that of the control group. In neurotraumatic disorders
such as spinal cord injury (SCI), 91% of 110 thoracolumbar SCI patients and 74%
of 56 cervical SCI patients showed improvement in spasticity, sensation, trunk
control, bladder management, standing and sitting balance, ambulation and
ADLs along with FIM, ASIA, and EMG/NCV; in traumatic brain injury (TBI), 93%
of 14 TBI patients displayed improved balance, voluntary control, muscle tone,
oromotor activities, cognition, coordination, speech, ambulation and ADLs after
intervention. In neurovascular disorders such as brain stroke, 24 patients those
who have brain stroke, better outcome was observed in patients with ischemic
stroke as compared to haemorrhagic stroke with improvement in ambulation,
hand function, standing and walking balance. We conclude that stem cell therapy
is a safe and an effective treatment option for the above clinical conditions

Biography

Dr. Gustavo Adolfo Uriza completed his medical degree
in 1992 and then his neurosurgical training in 1998 at the
same University. He has specialized studies in Colombia in
vascular, tumor, trauma and spine surgery. He is the director
of the Universidad de La Sabana School of Medicine since
2008. He has performed over 5000 surgical procedures
during his career, serves as President of Bogotá region
at the Colombian Association of Neurosurgery and has
published several papers in local and regional journals.

Abstract

Aneurismal subarachnoid haemorrhage (SAH) accounts for about 5% of
all cerebrovascular disease. It´s a common and frequently devastating
condition. In South America, estimated incidence is 9.1 cases for 100.000
population. American and European guidelines advise endovascular treatment
in highly specialized centers. However, developing countries lack sometimes
of such centers. In Colombia, due to our health system . endovascular centers
are just emerging and maturing. We compare our surgical series of the last
10 years with the result of endovascular centers, showing that, despite those
centers are relatively new, results are comparable to those on the literature.
Surgery also shows an important and prevailing role in contemporary treatment
of subarachnoid haemorrhage.

Biography

Shemsedin Dreshaj has completed his Medical Faculty in
Prishtina, Kosovo in 1984. He has worked as a Specialist in
Infectious Diseases at University Medical Centre Ljubljana,
Slovenia in 1991and Subspecialist in CNS infections
at Montefiore Medical Centre, NY, USA in 1996. He has
completed his PhD in 2003 from Faculty of Medicine in
Prishtina .He worked as Senior Infectious Diseases doctor
in Infectious Diseases Clinic Prishtina in 1990, Head of
Department for Neuroinfections (1992-2008), Head of ICU
Department in Infectious Diseases Clinic (2008-2018).
He was Head of Infectious Diseases Clinic (2006-2014),
Vice Dean for academic affair’s (2009-2013), Medical
Faculty in Prishtina. His research activities are focused on
neuroinfection and neurological disorder. He has published
more than 21 manuscripts in international journals, more
than 40 proceedings and presented several oral or poster
presentations in this field.

Abstract

Introduction: Septic cavernous sinus thrombosis (SCST) is a rare complication
associated with face and neck area infection. SCST is known for severe clinical
presentation, often complicated and bad outcome. Till now, there are no
randomized and controlled trials for management of this condition.
Objective: To describe clinical characteristics, treatment and outcome of
hospitalized confirmed SCST patients in Infectious Diseases Clinic in Prishtina,
Kosovo.
Methods: Clinical and laboratory data of 13 confirmed SCST cases treated in our
institution, were reviewed retrospectively.
Results: 13 cases of SCST in Infectious Diseases Clinic in Prishtina were treated
between the Jan’ 1st 1991 and Dec’ 31st 2017. Five cases did not survive the
disease (38.5%), three of 13 (23%) presented neurological complications at
discharge from the hospital. 12 cases presented purulent meningoecephalitis
and one sympathetic meningitis. In 12 (92.3%) cases, primary focus was in upper
part of the face. Ethological agent was identified in 11 (84.6%), and in 8 (61.5%),
it was Staphylococcus aureus. All patients were treated with anti edematous
therapy, antibiotics, corticosteroids, whereas 7 (53.8%) patients were treated with
anticoagulant therapy for four days. In one patient treated with anticoagulant
therapy, hemorrhagic complications were seen. Contrast enhanced CT of head
was 100% sensitive in detection of SCST, whereas contrast MRI confirmed SCST
in only one of the four cases.
Conclusions: The prognosis of SCST now a day is more favourable than before.
Anti-coagulants seem to be a safe addition treatment to antibiotic, also in patients
with SCST and central nervous system infection

Biography

Mohamed Gohary is working as Neurosurgery MD at
Alexandria University and Consultant of Neurosurgery. Also
Member in NAAS. Member in ESA and Member in ENS.

Abstract

Background: Spinal epidural abscess is very annoying problem, which needs
an immediate medical attention. Its presence within the cervical spine is life
threating issue because of the vital functions that can be compromised as a result
from just the compression effect. So the concept of the bony decompression is
essential in such cases.
Aim: To describe a rare presentation of spinal epidural abscess, a case report of
an extensive epidural abscess within the cervical spinal region.
Results: Case report of cervical epidural abscess in 56 year old male from Rosetta
complained of acute onset of neck pain for about 2 months, with progressive
course of upper and lower limbs weakness and with no sphincter affection.
Patient has not undergone any neck and back surgery previously. Patient has a
history of renal impairment and on medical treatment for about 4 years. Magnetic
Resonance imaging of the cervical spine, showed ventral cervical spinal cord
compression by an epidural abscess extending from the apex of dens to the level
of C5. Surgical intervention via anterior approach and corpectomy of the C4 and
C5, iliac crest graft with plate and screws fixation was done. About 3 months
after surgery, the patient markedly improved and was able to perform the usual
lifestyle activities.
Conclusion: Diagnosing patient with epidural abscess within the cervical spine is
somewhat a difficult suspecting issue in patient with no history of chronic illness
nor previous spine surgery. Evacuation of the abscess and corpectomy of the
friable pathological levels, fusion with iliac crest graft and fixation with plate and
screws was a suitable option in management of this case.

Biography

Ivet Borissova Koleva is a Medical Doctor, specialist in
Neurology and in Physical & Rehabilitation Medicine
(PRM) with 30 years of clinical practice in the domain
of Neurorehabilitation. She has completed a PhD
thesis on Physical Prevention and Therapy of Diabetic
Polyneuropathy and a thesis for Doctor of Medical
Sciences on Neurorehabilitation in patients with socially
important neurological diseases. She received the titles of
Associate professor (2006) and Professor (2010) in PRM.
Currently, she is serving as a Professor in the Medical
University of Sofia, Bulgaria. She is also the consulting
PRM specialist of several university hospitals, including
the National Heart Hospital of Sofia (Cardiorehabilitation
Department). She is the author of scientific papers,
monographs and manuals in the fields of Physical Medicine
and Rehabilitation, occupational therapy, Grasp and Gait
rehabilitation, functional evaluation, pain management. She
is the Member of national and international associations
of PRM and President of Bulgarian Neurorehabilitation
Society and Editor-in-chief of the Bulgarian scientific journal
Neurorehabilitation (since 2006).

Abstract

Introduction: After valve replacement cardiosurgery (with extracorporeal
circulation), some patients develop cerebrovascular insufficiency in the vertebrobasilar
system with balance problems or ataxia signs. Our goal was to evaluate
the prevalence of cerebrovascular insufficiency in old patients after cardiac
surgery with extracorporeal circulation and to investigate the possible impact
of balance training in the complex cardiac rehabilitation (CR) algorithm of these
patients.
Material & Methods: We have observed 213 patients after cardiac surgery (7-10
days after aortic, mitral or tricuspid valve replacement). Patients were randomized
into three therapeutic groups (71 per group). The control was done before, during
and at the end of the CR course (of 10 treatment days), and one month after its
end-using a battery of clinical methods and functional scales. In all patients, we
applied a complex cardio-rehabilitation (CR) programme of physiotherapy and
ergotherapy including cardio training, respiratory exercises (predominantly for
external and internal intercostal muscles) and goal-oriented activities (standing
up, walking and climbing stairs). Group (gr) 1, received only this CR programme.
In gr 2, we added balance training exercises. In the next group (gr 3), we applied
additionally coordination exercises for the upper and lower extremities.
Results: The statistical analysis of the results of functional assessments
demonstrated significant improvement of circulatory parameters (response
of arterial tension and pulse to physical activity); upgrade in cardiac functional
parameters (holtercardiography; transthoracic echocardiography /ejection
fraction), enlargement in autonomy (timed up and go test; functional independence
measure–subscales of self-care, transfers and locomotion) in all patients. We
observed bigger amelioration in trunk stability, balance and gait velocity in the
second and the third groups (Tinetti test, Berg balance scale).
Conclusion: Balance training must be obligatory element of cardiorehabilitation
algorithm in patients after cardiosurgery requiring extra-corporeal circulation

Biography

Dr. Gustavo Adolfo Uriza completed his medical degree
in 1992 and then his neurosurgical training in 1998 at the
same University. He has specialized studies in Colombia in
vascular, tumor, trauma and spine surgery. He is the director
of the Universidad de La Sabana School of Medicine since
2008. He has performed over 5000 surgical procedures
during his career, serves as President of Bogotá region
at the Colombian Association of Neurosurgery and has
published several papers in local and regional journals.

Abstract

Vertebral osteoporotic fractures are an increasing cause of back pain and
disability, especially in the elderly population. Open surgery for the treatment
of those fractures may involve high risks in these patients, creating the need
of less invasive procedures. Vertebroplasty initially led to controversial results,
but the use of high viscosity cements and the depuration of the techniques
have shown real benefit in the last years. We describe our experience with
vertebroplasty alone and other augmentation techniques since 2005, showing
increase in the daily performance of elderly patients after osteoporotic fractures.
We also explore new frontiers for these techniques

Biography

Assistant Lecturer at the Future University of Egypt
(FUE) and NODCAR {National Organization for Drug
Control and Research}. Reviewer at Bioscience reports
journal, Biochemical Society (neuroscience). Eight years’
experience as QA&QC. Highly trained and qualified to
deal/work on: Mesenchymal stem cells homing and
developing techniques, PCR, western blotting technique,
electrophoresis, Elisa, spectrophotometer, HPLC, dissolution
and disintegration. Successfully trained & passed the QMS
ISO 9001:2008 documentation, implantation training &
internal audit.

Abstract

Neurocognitive disorders have been characterized by being a devastating
long-term neurological disease with a huge social and economic impact.
Alzheimer's disease (AD) is the most common type of dementia accompanied
with decline in cognitive functions. Objectives: The main aim of this study is to
suggest therapeutic protocol having the potentials for restoring and modifying
neuropathological deposited hallmarks including both positive and negative
lesions such as amyloid plaques, tau protein and synaptic loss. Materials and
Methods :Rats were divided into nine groups:(G1) control;(G2) rats received
lipopolysaccharide (LPS) as a method of inducing nongenetically manipulated
neuroinflammatory AD type ;(G3) AD rats received NaHS; (G4) AD rats received
mesenchymal stem cells (MSCs) intracerebrally; (G5)AD rats received
MSCs+NaHS ; (G6) AD rats received kefir+Ginko Biloba (GB); (G7) AD rats received
MSCs+ kefir+GB;(G8)AD rats received NaHS+kefir+GB; (G9)AD rats received
MSCs+NaHS+kefir+GB. Results: The induction of AD resulted in downregulation of
cystathionine β-synthase enzyme (CBS) relative gene expression and Glutathione
(GSH) brain tissue level accompanied with overexpression in amyloid-β
protein, mitogen-activated protein kinases (MAPK), tau protein, ACAT(Acyl-
CoA:cholesterol Acyl transferase) relative gene expression and Malondialdehyde
(MDA) brain tissue level in addition to elevated caspase-3 serum activity level.
Conclusion: The present study clearly proved the beneficial role of NaHS as
exogenous H2S donor in attenuating AD drawbacks mainly through CBS/H2S
overexpression enhancing the degradation of Aβ deposited plaques in addition to
the ability of MSCs administrated locally to develop into different types of neural
cells to compensate damaged ones. Regarding the role of administrating Kefir
and GB in maintaining normal brain functions suggested to be as a result of their
synergistic antioxidant and anti-apoptotic actions

Biography

Fathi Mahmoud Afifi Nasra has started his career in 1976
and completed his Master’s degree in 1979 and PhD in
1984, respectively. He was promoted to Associate Professor
of Neurology in Al-Azhar University in 1989. Then, he was
promoted to Professor of Neurology inthe same University
in 1994..He was elected as the Editor in Chief of Journal of
Egyptian stroke, board of the Journal of Neurology, Psychiatry
and Neurosurgery and board of Al-Azhar medical journal, in
1999. He was awarded the annual National Research Academy
Award for Neurology (Osama Elwan).In 2003; he was promoted
to a Chairman Of Neurology Departmentof Al-Azhar University
and Secretary of Permanent Scientific Commite to promote
professor and assistant professor in Neurology. He established
the Neurocritical Care Unit and Interventional unit in Al-Azhar
university Hospitals in 2004. Now, he is the President of
Egyptian Stroke Society.

Abstract

Many aspects of stroke have been extensively studied; the prognosis of
acute ischemic stroke is one of these aspects. Also many studies directed to
early spontaneous or induced (artificial) recanalization by using thrombolytic
therapy, relay on early restoring of blood flow.
Aim of the study: To evaluate the prognostic value of recanalization in acute
ischemic stroke by using cerebral angiography in correlation with clinical
outcome and brain C T scan findings.
Subjects & Methods: This study was conducted on 16 patients out of 50
patients, who came to the emergency department of Al-Azher university
hospitals from Mar’ 2003 to Mar’ 2005. All patients included in the study, came
within 6-8 hours from ischemic stroke onset and age greater than 18 years
(thrombolytic therapy may be needed). All selected patients were subjected to
the following: history taking, general and neurological examination including
National Institute of Health Stroke Scale (NIHSS). CT scan of brain was
performed at the time of admission to exclude cerebral haemorrhage, mass
lesion and was repeated when needed. Laboratory investigation, cerebral
angiography was performed at the first 6-8 hrs of admission, to detect the site
of occlusion and recombinant tissue plasminogen activator (rtPA) injection in
appropriate cases and repeated after 24 hrs, to detect early recanalization.
Results: There was statistically significant difference in angiographic findings
as regard outcome, higher frequency of recanalization level among good
outcome group (P<0.05), statistically significant difference in D M distribution
as regard outcome, higher frequency of D M among bad outcome group
(P<0.05), statistically significant difference in time of onset distribution as
regard outcome, higher frequency of late onset among bad outcome (P<0.05).
Conclusion: Patient with stroke and no documented angiographic occlusion
(spontaneous recanalization) must be withdrawn from thrombolytic therapy
.Cerebral angiography can be done for ischemic stroke patients, who are
candidates for thrombolytic therapy.